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Green synthesis of new pyrimido[4,5‐d]pyrimidine derivatives using 7‐aminonaphthalene‐1,3‐disulfonic acid‐functionalized magnetic Fe 3 O 4 @SiO 2 nanoparticles as catalyst
Author(s) -
GhorbaniVaghei Ramin,
Sarmast Narges
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4003
Subject(s) - chemistry , reagent , catalysis , pyrimidine , isothiocyanate , solvent , magnetic nanoparticles , nanoparticle , green chemistry , combinatorial chemistry , reaction conditions , organic chemistry , nanotechnology , reaction mechanism , stereochemistry , materials science
We, herein, describe a novel, simple, efficient and one‐pot multi‐component procedure for the synthesis of substituted pyrimido[4,5‐d]pyrimidines via reaction of N,N ‐dimethyl‐6‐amino uracil, isothiocyanate and aromatic aldehydes promoted by 7‐aminonaphthalene‐1,3‐disulfonic acid (ANDSA)‐functionalized magnetic Fe 3 O 4 @SiO 2 in water as solvent and without using any other harmful organic reagents. Compared with other reactions, using these organic–inorganic hybrid heterogeneous catalysts can help us to achieve a green procedure, high catalytic activity, easy recovery with an external magnetic field, and short reaction times.