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Synthesis of innovative biochemical active mixed ligand metal(II) complexes with thiazole containing Schiff base: In vitro antimicrobial profile
Author(s) -
Raman Natarajan,
Chandrasekar Thiravidamani,
Kumaravel Ganesan,
Mitu Liviu
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3922
Subject(s) - chemistry , schiff base , ligand (biochemistry) , thiazole , intercalation (chemistry) , salicylaldehyde , gel electrophoresis , metal , combinatorial chemistry , polymer chemistry , stereochemistry , inorganic chemistry , organic chemistry , biochemistry , receptor
An unique Schiff base ligand, formed by the condensation reaction of 2‐aminobenzothiazole with curcumin and its Cu(II), Ni(II), Co(II) and Zn(II) complexes incorporating 2,2′‐bipyridine as coligand were synthesised. They were characterized via analytical and spectroscopic methods. The complexes adopt square planar geometry. Their antimicrobial activity and photocatalytic efficiency on Congo red dye molecule were explored. It is found that all the complexes are antimicrobial active and show higher activity than the ligand. The nuclease activity of the above metal complexes was also assessed by absorption titration, fluorescence, viscosity and gel electrophoresis assay. The complexes bind CT DNA through intercalation mode. The data reveal that the above synthesised metal(II) complexes are found to be effective metallonucleases. The gel electrophoresis results exhibit that the metal complexes cleave pBR322 plasmid DNA in presence of hydrogen peroxide effectively compared to the ligand. The synthesised metallonucleases should lead to a new era for the logical sketch of dominant agents for probing and targeting nucleic acids. This exploration reveals that Cu(II) complex has a valued biological and photochemical profile.