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Synthesis, structural features and biochemical activity assessment of N,N′‐bis‐(2‐mercaptophenylimine)‐2,5‐thiophenedicarboxaldehyde Schiff base and its Co(II), Ni(II), Cu(II) and Zn(II) complexes
Author(s) -
Abdel Aziz Ayman A.,
Seda Sabry H.
Publication year - 2017
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3879
Subject(s) - chemistry , schiff base , molar conductivity , deprotonation , ligand (biochemistry) , tetrahedral molecular geometry , metal , magnetic susceptibility , radical , proton nmr , copper , carbon 13 nmr , metal ions in aqueous solution , crystallography , inorganic chemistry , stereochemistry , ion , organic chemistry , biochemistry , receptor
The tetradentate Schiff base ligand (SB), N,N′‐bis‐(2‐mercaptophenylimine)‐2,5‐thiophenedicarboxaldehyde was prepared via condensation of 2,5‐thiophene‐dicarboxaldehyde with 2‐aminothiophenol in a 1:2 molar ratio by conventional method. Additionally, its Co(II), Ni(II), Cu(II) and Zn(II) complexes have been synthesized and fully characterized by elemental analysis, FT‐IR, 1 H NMR, 13 C NMR, UV–Vis, ESR, ESI‐mass, conductivity and magnetic susceptibility measurements. Spectral studies suggested that, the Schiff base coordinate metal ions through the azomethine N‐ and deprotonated thiol S‐ atoms. Based on UV–Vis absorption and magnetic susceptibility data, tetrahedral geometry was assigned for both Co(II) and Zn(II) complexes, whereas on the other hand, square planar geometry for both Ni(II) and Cu(II) complexes. The Schiff base and its metal complexes were screened for their in vitro antimicrobial activity by minimum inhibitory concentration (MIC) method. Free radical scavenging activity of the novel compounds was determined by elimination of 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radicals. In addition, the interactions of the free ligand and its complexes with calf thymus DNA (CT‐DNA) were explored using absorption, emission and viscosity measurements techniques.