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Mononuclear metal (II) complexes of a Bis(organoamido)phosphate ligand with antimicrobial activities against Escherichia coli
Author(s) -
Pal Souvik,
Tarafdar Abhrajyoti,
Sinha Alok,
Bhunia Asamanjoy,
Harms Klaus,
Nayek Hari Pada
Publication year - 2017
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3821
Subject(s) - chemistry , isostructural , ligand (biochemistry) , metal , octahedron , crystallography , crystal structure , metal ions in aqueous solution , stereochemistry , inorganic chemistry , medicinal chemistry , organic chemistry , biochemistry , receptor
A new tripodal ligand [PO(NH 2 MePy) 3 ] ( L ) ( 2 MePy = 2‐(4‐methyl pyridyl)) have been synthesized by treating phosphorous oxychloride with 2‐Amino‐4‐methylpyridine in toluene under refluxing condition. The ligand was appeared as a white solid and characterized by several standard analytical and spectroscopic techniques such as FT‐IR, NMR ( 1 H, 13 C{ 1 H} and 31 P{ 1 H}) and ESI‐MS spectroscopy. The ligand ( L ) undergone metal‐assisted hydrolysis of one P–N bond when treated it with hydrated metal nitrates, M(NO 3 ) 2 ·xH 2 O (M = Zn, Cu, Co and Ni) under hydrothermal reaction condition in DMF‐H 2 O (1:1). This results in the formation of four mononuclear complexes [{PO 2 (NH 2 MePy) 2 } 2 M] [M = Zn ( 1 ), Cu ( 2 ), Co ( 3 ), Ni ( 4 )], where ligand ( L ) hydrolyses to a anionic bis(organoamido)phosphate, [PO 2 (NH 2 MePy) 2 ] − . All complexes were completely characterized by various analytical techniques and their solid state molecular structures were established by single crystal X‐ray diffraction. All complexes are isostructural with a metal (II) ion situating at the centre of a distorted octahedron. Two tridentate [PO 2 (NH 2 MePy) 2 ] − ligands are coordinated to metal(II) ion through N‐ and O‐donor atoms, thus neutralizing the charge of the complex. Optical properties of all complexes in solid state have been studied. Moreover, antimicrobial activities of complexes 1 – 4 have been explored. To the best of our knowledge, this is the first report of such compounds investigated for their antimicrobial activities.