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Synthesis and antimicrobial activity of bulky 3,5‐di‐ tert ‐butyl substituent‐containing silver–N‐heterocyclic carbene complexes
Author(s) -
Kaloğlu Nazan,
Özdemir İlknur,
Günal Selami,
Özdemir İsmail
Publication year - 2017
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3803
Subject(s) - chemistry , carbene , candida tropicalis , antimicrobial , escherichia coli , enterococcus faecalis , candida albicans , substituent , pseudomonas aeruginosa , carbon 13 nmr , stereochemistry , staphylococcus aureus , medicinal chemistry , microbiology and biotechnology , organic chemistry , bacteria , catalysis , biochemistry , yeast , genetics , biology , gene
A series of novel benzimidazolium bromides containing bulky 3,5‐di‐ tert ‐butyl group were synthesized in high yields as N‐heterocyclic carbene (NHC) ligands. These NHC ligands were metallated with Ag 2 O under moderate conditions to give novel silver–NHC complexes. The structures of all compounds were characterized using 1 H NMR, 13 CNMR, infrared and elemental analysis techniques, which supported the proposed structures. The silver–NHC complexes were screened for their in vitro antimicrobial activities against the standard bacterial strains Enterococcus faecalis , Staphylococcus aureus , Escherichia coli and Pseudomonas aeruginosa and the fungal strains Candida albicans and C. tropicalis . The results showed that most of the silver–NHC complexes inhibited the growth of all bacterial strains and fungal strains and were found to display effective antimicrobial activity against different microorganisms.