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Hydrothermal preparation and characterization of ZnFe 2 O 4 magnetic nanoparticles as an efficient heterogeneous catalyst for the synthesis of multi‐substituted imidazoles and study of their anti‐inflammatory activity
Author(s) -
Marzouk Adel A.,
AbuDief Ahmed M.,
Abdelhamid Antar A.
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3794
Subject(s) - chemistry , catalysis , thermogravimetric analysis , benzil , nanoparticle , yield (engineering) , magnetic nanoparticles , heterogeneous catalysis , infrared spectroscopy , nuclear chemistry , chemical engineering , organic chemistry , materials science , engineering , metallurgy
Nanoparticles are key focus of research for a wide range of novel applications. As such, ZnFe 2 O 4 magnetic nanoparticles were synthesized hydrothermally and characterized via scanning and transmission electron microscopies, powder X‐ray diffraction, energy‐dispersive X‐ray and infrared spectroscopies, thermogravimetric analysis and magnetic measurements. They were used as a robust catalyst for the synthesis of a series of biologically active multi‐substituted imidazoles using a multicomponent reaction by the reaction of benzil with various aromatic aldehydes, ammonium acetate and aliphatic amines ( N , N ‐dimethyl‐1,3‐propanediamine and 1‐amino‐2‐propanol) under solvent‐free conditions. The key advantages of this method are shorter reaction times, very high yield and ease of operation. The thermally and chemically stable, benign and economical catalyst was easily recovered using an external magnet and reused in at least five successive runs without an appreciable loss of activity. All of these novel synthesized compounds were characterized from spectral data and their purities were checked using thin‐layer chromatography, giving one spot. Furthermore, the prepared compounds were tested for their anti‐inflammatory activity.