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Synthesis and biological activity of novel N ‐benzoyl‐ N ‐ tert ‐butyl‐ N ′‐(β‐triphenylgermyl)propionylhydrazines
Author(s) -
Wang QingMin,
Cheng JunRan,
Huang RunQiu
Publication year - 2002
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.377
Subject(s) - chemistry , bioassay , propanoic acid , biological activity , in vitro , stereochemistry , medicinal chemistry , biochemistry , genetics , biology
A series of new N ‐benzoyl‐ N ‐ tert ‐butyl‐N′‐(β‐triphenylgermyl)propionylhydrazines were synthesized by the condensation reaction of β‐triphenylgermyl propanoic acid with N ‐benzoyl‐ N ‐ tert ‐butylhydrazines in good yields by using N , N ′‐dicyclohexylcorbodiimide as dehydrating agent. These title compounds were evaluated for molting hormone mimicking activity. The results of bioassay showed that the compounds exhibit moderate larvicidal activity, and toxicity assays indicated that the title compounds can induce a premature, abnormal and lethal larval molt. We found that the title compounds possess potential anticancer activities in vitro . Copyright © 2002 John Wiley & Sons, Ltd.