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Modified cyclopentadienyl molybdenum compounds with enhanced cytotoxic activity towards MOLT‐4 leukaemia cells
Author(s) -
Honzíčková Iva,
Vinklárek Jaromír,
Růžičková Zdeňka,
Řezáčová Martina,
Honzíček Jan
Publication year - 2017
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3759
Subject(s) - chemistry , cyclopentadienyl complex , molybdenum , halogen , chelation , crystal structure , stereochemistry , medicinal chemistry , crystallography , inorganic chemistry , organic chemistry , catalysis , alkyl
A series of new cyclopentadienyl molybdenum compounds bearing substituted phenanthroline ligands [(η 5 ‐C 5 H 4 CH 2 C 6 H 4 X‐4)Mo(CO) 2 ( N,N L)][BF 4 ] (X = F, Cl, Br; N,N L = phen, 5‐NH 2 ‐phen, 4,7‐Ph 2 ‐phen) was prepared and characterized using infrared and NMR spectroscopies. Crystal structures of [(η 5 ‐C 5 H 4 CH 2 C 6 H 4 F‐4)Mo(CO) 2 (NCMe) 2 ][BF 4 ], [(η 5 ‐C 5 H 4 CH 2 C 6 H 4 X‐4)Mo(CO) 2 (phen)][BF 4 ] (X = F, Cl, Br) and [(η 5 ‐C 5 H 4 CH 2 C 6 H 4 Cl‐4)Mo(CO) 2 (4,7‐Ph 2 ‐phen)][BF 4 ]⋅(4,7‐Ph 2 ‐phen)⋅HBF 4 were determined using X‐ray diffraction analysis. Biological studies revealed a strong cytotoxic effect of the chelating ligands. Although the cytostatic effect of the halogen in the side chain of the cyclopentadienyl ring is negligible, it could be used for future post‐modification of these types of cytotoxic active molybdenum‐based compounds.