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Synthesis of retinoid analogues of juvenile hormones
Author(s) -
Doumandji Lotfi,
Matondo Hubert,
Estaran Sébastien,
Hamada Boudjema,
Lagneau Christophe,
Devillers James,
Yébakima André,
DoucetPanaye Annick,
Doucet JeanPierre,
Lattes Armand
Publication year - 2017
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3736
Subject(s) - chemistry , juvenile hormone , retinoic acid , hormone , ketone , retinoid , combinatorial chemistry , chemical synthesis , organic chemistry , biochemistry , in vitro , gene
As part of a collaborative research project aimed at designing new chemicals active on mosquito larvae, we sought accessible raw materials and an efficient synthesis method for preparing large amounts of active substances. For this we selected retinoic acid, which has functionality close to that of juvenile hormones. From this molecule we developed ester and trifluoromethyl ketone synthesis that was fast and led to good yields.