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Effect of solvent coordination on the structure of β‐diketone‐based vanadyl complexes and assessment of in vitro antidiabetic activity and cytotoxicity
Author(s) -
Chinthala Chinna Pullaih,
Angappan Sheela
Publication year - 2017
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3700
Subject(s) - chemistry , hela , dichloromethane , cytotoxicity , solvent , dimethylformamide , nuclear chemistry , electrospray ionization , crystal structure , electron paramagnetic resonance , diketone , stereochemistry , mass spectrometry , in vitro , crystallography , organic chemistry , nuclear magnetic resonance , chromatography , biochemistry , physics
The physicochemical properties, thereby the biological efficacy, of metal complexes are affected based on their structure and geometry that vary in the presence of coordinating and non‐coordinating solvents. To investigate this, in the present work, we synthesized three hitherto unreported β‐diketone‐based oxovanadium(IV) complexes, namely [VO(tfdmh) 2 ] (tfdmh =1,1,1‐trifluro‐5,5‐dimethyl‐2,4‐hexanedione), [VO(dmh) 2 ] (dmh = 2,2‐dimethyl‐3,5‐hexanedione) and [VO(dbm) 2 ] (dbm = 1,3‐diphenylpropane‐1,3‐dione), and characterized them using electron paramagnetic resonance, UV–visible, Fourier transform infrared and electrospray ionization mass spectroscopies and single‐crystal X‐ray diffraction. The structural changes in the presence of dichloromethane, dimethylsulfoxide and dimethylformamide were analysed using spectroscopic techniques. Further, in vitro glucose uptake efficacy and cytotoxicity were assessed using C2C12 (rat skeletal muscle) and HeLa (human cervical cancer) cell lines, respectively.