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Synthesis, characterization and cytotoxicity of platinum(II) complexes containing reduced amino acid ester Schiff bases
Author(s) -
Yan QinQin,
Yuan Zhen,
Liu GuoJun,
Lv ZhengHua,
Fu Bin,
Du JianLong,
Li LiJun
Publication year - 2017
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3689
Subject(s) - chemistry , molar conductivity , hela , circular dichroism , schiff base , cytotoxicity , platinum , proton nmr , cisplatin , infrared spectroscopy , elemental analysis , amino acid , stereochemistry , nuclear chemistry , in vitro , polymer chemistry , organic chemistry , biochemistry , catalysis , chemotherapy , medicine , surgery
Nine platinum(II) complexes containing reduced amino acid ester Schiff bases were synthesized and characterized using spectroscopy ( 1 H NMR, 13 C NMR, infrared), elemental analysis and molar conductivity. The interaction of these complexes with salmon sperm DNA was investigated by means of ultraviolet and circular dichroism spectroscopies. The potential antitumor activity of all compounds was tested in vitro on HeLa and A549 tumor cell lines. Almost all the complexes exhibited better cytotoxic activity than cisplatin against these cell lines.