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Synthesis, characterization and anticancer activity of a series of curcuminoids and their half‐sandwich ruthenium(II) complexes
Author(s) -
Li Peiyuan,
Su Wei,
Lei Xiaolin,
Xiao Qi,
Huang Shan
Publication year - 2017
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3685
Subject(s) - chemistry , hela , ruthenium , electrospray ionization , mass spectrometry , elemental analysis , in vitro , stereochemistry , nuclear chemistry , combinatorial chemistry , organic chemistry , chromatography , biochemistry , catalysis
A series of curcuminoids (L 1 –L 7 ) and their corresponding (η 6 ‐ p ‐cymene)Ru II (Cur)Cl complexes ( 1 – 7 ) were synthesized and characterized using 1 H NMR spectroscopy, elemental analysis and high‐resolution electrospray ionization mass spectrometry. The molecular structures of L 2 , L 4 , 1 and 4 were determined using single‐crystal X‐ray diffraction analysis. The stability of 1 – 7 was investigated by monitoring their UV profiles. The compounds were further evaluated for their in vitro antiproliferative activities against the HepG2 human liver and HeLa human cervical cancer cell lines and HEK‐293 T noncancerous cell line.