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Synthesis and characterization of binary and ternary oxovanadium complexes of N , N ′‐(2‐pyridyl)thiourea and curcumin: Catalytic oxidation potential, antibacterial, antimicrobial, antioxidant and DNA interaction studies
Author(s) -
Adam Mohamed Shaker S.,
Youssef Magdy M.,
Aboelghar Maha F.,
Hafez Aly M.,
ElAyaan Usama
Publication year - 2017
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3650
Subject(s) - chemistry , thiourea , acetonitrile , catalysis , ternary operation , ternary complex , medicinal chemistry , nuclear chemistry , combinatorial chemistry , inorganic chemistry , organic chemistry , enzyme , computer science , programming language
Two binary and two ternary mono‐oxovanadium (IV) complexes of acetylacetonate, curcumin and N , N ′‐bis(2‐pyridyl)thiourea were synthesized. They were characterized using elemental analysis, infrared and UV–visible spectroscopies and magnetic and conductivity measurements. The formation constants K f were determined from spectrophotometric measurements. The catalytic potential of the VO complexes was investigated for the oxidation of 1‐octene by aqueous H 2 O 2 in acetonitrile. They display high catalytic potential for the conversion of 1‐octene with low chemoselectivity to the epoxy product. The VO complexes exhibit good antibacterial and antimicrobial activities. The antioxidant activity of the VO complexes and their ligands was investigated. The VO complexes show high DNA affinity and DNA cleavage ability.