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Synthesis, characterization and antimicrobial activity of triorganotin(IV) derivatives of some bioactive Schiff base ligands
Author(s) -
Bhatra Pooja,
Sharma Jyoti,
Sharma Ram Avatar,
Singh Yashpal
Publication year - 2017
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3639
Subject(s) - chemistry , tin , schiff base , tetrahydrofuran , medicinal chemistry , metal , chloride , stereochemistry , base (topology) , proton nmr , nuclear magnetic resonance spectroscopy , antimicrobial , organic chemistry , mathematical analysis , mathematics , solvent
Triorganotin(IV) complexes of the type Me 3 Sn[OC(R 1 ):CH(CH 3 )C:NR 2 OH] and Ph 3 Sn[OC(R′):CH(CH 3 )C:NR″OH] (R′ = ─CH 3 , ─C 6 H 5 ; R″ = ─(CH 2 ) 2 ─, ─(CH 2 ) 3 ─) have been synthesized by the reactions of trimethyl/phenyltin(IV) chloride with the sodium salt of corresponding Schiff base ligands in unimolar ratio in refluxing tetrahydrofuran. All these compounds have been characterized using elemental analyses and their probable structures have been proposed on the basis of infrared, 1 H NMR, 13 C NMR, 119 Sn NMR and mass spectroscopic studies. In the trimethyltin(IV) derivatives the central tin atom is tetracoordinated, whereas in the analogous triphenyltin(IV)derivatives the central tin atom is pentacoordinated. All these ligands, metal precursors and corresponding triorganotin(IV) complexes have been screened for antimicrobial activities. A comparison of activities of the ligands and their corresponding triorganotin(IV) derivatives has been made. Attempts have also been made to relate the activity to the structure of these compounds.