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Synthesis and structural characterization of new bioactive ligands and their Bi(III) derivatives
Author(s) -
Raheel Ahmad,
Andleeb Sohaila,
Ramadan Simko,
Tahir Muhammad Nawaz
Publication year - 2017
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3632
Subject(s) - chemistry , thiourea , urease , antimicrobial , carbon 13 nmr , enzyme , antioxidant , nuclear chemistry , carboxylic acid , antifungal , combinatorial chemistry , organic chemistry , stereochemistry , medicine , dermatology
Five new carboxylic acid precursors bearing thiourea group and their corresponding bismuth(III) complexes were synthesized and characterized using CHNS and inductively coupled plasma analyses and infrared and NMR ( 1 H, 13 C) spectroscopies. Single‐crystal X‐ray diffraction analysis was also carried out for one of the precursors. The behaviour of the compounds was bioassayed for antibacterial, antifungal, antioxidant and enzyme (lipoxygenase, α‐glycosidase and anti‐urease) inhibition activities. It is concluded that the interaction of the compounds with bismuth enhances both the antimicrobial and enzyme inhibition activities. The synthesized compounds may prove to be good therapeutic agents.