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Palladium‐catalyzed highly selective intramolecular bromoamination of alkenes: Efficient synthesis of substituted pyrrolidines
Author(s) -
Zhang Jingfang,
Wang Xie,
Liu Yulong,
Wang Xiaoyun,
He Wei
Publication year - 2017
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3631
Subject(s) - chemistry , intramolecular force , pyrrolidine , catalysis , palladium , selectivity , combinatorial chemistry , reaction conditions , organic chemistry
A new method has been developed for the preparation of substituted pyrrolidines by the palladium‐catalyzed intramolecular bromoamination of substituted aminoalkenes. The catalytic system and reaction conditions used for this transformation have been fully optimized. Notably, this reaction exhibits excellent selectivity, affording the pyrrolidine products as single 5‐exo‐bromoalkylpyrrolidines in excellent yields. Furthermore, this reaction occurs at room temperature under mild conditions, reaching completion within 1 h.