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Synthesis, structure and antiproliferative activity of organometallic iridium(III) complexes containing thiosemicarbazone ligands
Author(s) -
Su Wei,
Peng Binghua,
Li Peiyuan,
Xiao Qi,
Huang Shan,
Gu Yunqiong,
Lai Zefeng
Publication year - 2017
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3610
Subject(s) - chemistry , semicarbazone , hela , iridium , cisplatin , stereochemistry , absorption spectroscopy , crystallography , crystal structure , density functional theory , group 2 organometallic chemistry , coordination complex , in vitro , molecule , metal , computational chemistry , organic chemistry , biochemistry , catalysis , medicine , physics , surgery , chemotherapy , quantum mechanics
A series of half‐sandwich iridium complexes ( 1 – 4 ) with thiosemicarbazone ligands in two types of coordination modes were synthesized and characterized. The molecular structures of compounds 1 , 2 and 3 were determined using single‐crystal X‐ray diffraction analysis. The nature of the complexes was studied using density functional theory calculations. The stability of the complexes was investigated using UV–visible absorption spectroscopy. The compounds were further evaluated for their in vitro antiproliferative activities against HeLa, HepG2, CNE‐2, SGC‐7901, KB and HEK‐293 T cell lines. Compound 2 displays the highest antiproliferative activity among the other analogues and cisplatin.