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Design, synthesis, characterization and biological studies of copper(II) complexes with 2‐aminobenzimidazole derivatives as biomimetic agents
Author(s) -
Joseph J.,
Suman A.,
Balakrishnan Nisha
Publication year - 2017
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3585
Subject(s) - chemistry , acetylacetone , knoevenagel condensation , copper , proton nmr , carbon 13 nmr , fourier transform infrared spectroscopy , photochemistry , polymer chemistry , inorganic chemistry , stereochemistry , organic chemistry , catalysis , physics , quantum mechanics
Four novel copper(II) complexes of 2‐aminobenzimidazole derivatives (obtained from the Knoevenagel condensation of acetylacetone (obtained from acetylacetone and halogen‐substituted benzaldehydes) and 2‐aminobenzimidazole) were synthesized. They were characterized using elemental analysis, molar conductance measurements, and fast atom bombardment mass, Fourier transform infrared, NMR, UV–visible and electron paramagnetic resonance spectroscopies. On the basis of the spectral studies, a distorted square planar geometry was assigned for all the complexes. The antibacterial screening of the ligands and their complexes revealed that all the complexes had higher activities than the free ligands. Superoxide dismutase and antioxidant activities of the copper complexes were also studied. The shifts in Δ E p , E 1/2 , I pc and I pa values were explored for the interaction of the complexes with calf thymus DNA using the electrochemical technique.