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Metal–organic framework of amine‐MIL‐53(Al) as active and reusable liquid‐phase reaction inductor for multicomponent condensation of Ugi‐type reactions
Author(s) -
Rostamnia Sadegh,
Jafari Maryam
Publication year - 2017
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3584
Subject(s) - chemistry , amine gas treating , isocyanide , aldehyde , yield (engineering) , condensation reaction , condensation , solvent , metal , phase (matter) , organic synthesis , organic chemistry , combinatorial chemistry , polymer chemistry , catalysis , materials science , physics , metallurgy , thermodynamics
Metal–organic framework of NH 2 ‐MIL‐53(Al), with coordinative unsaturated aluminium sites, has been shown to be active in the Groebke–Blackburn–Bienaymé multicomponent coupling reaction based on Ugi‐type amine and aldehyde condensation over isocyanide and then a cyclization process. Interestingly this reaction occurred under solvent‐free conditions with high yield, in which the NH 2 ‐MIL‐53(Al) could be recovered and reused for five reaction cycles, giving a total turnover number of 455.