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Investigation of pharmacophore and antipharmacophore features of certain dimethyltin(IV) complexes of flexible N‐protected amino acids and fluorinated β‐diketone/β‐diketones
Author(s) -
Maheshwari Karuna,
Srivastava Manish Kumar,
Saxena Sanjiv,
Jain Asha
Publication year - 2017
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3570
Subject(s) - chemistry , diketone , stereochemistry , pharmacophore , antibacterial activity , medicinal chemistry , tin , organic chemistry , bacteria , genetics , biology
A set of pentacoordinated dimethyltin(IV) complexes of flexible N‐protected amino acids and fluorinated β‐diketone/β‐diketones was screened for their antibacterial activity against Pseudomonas aeruginosa , Staphylococcus aureus and Streptomyces griseus . These pentacoordinated complexes of the type Me 2 SnAB (where : R = CH(CH 3 )C 2 H 5 , A 1 H; CH 2 CH(CH 3 ) 2 , A 2 H; CH(CH 3 ) 2 , A 3 H; CH 2 C 6 H 5 , A 4 H; and BH = R'C(O)CH 2 C(O)R″: R′ = C 6 H 5 , R″ = CF 3 , B 1 H; R′ = R″ = CH 3 , B 2 H; R′ = C 6 H 5 , R″ = CH 3 , B 3 H; R′ = R″ = C 6 H 5 , B 4 H) were generated by the reactions of dimethyltin(IV) dichloride with sodium salts of flexible N‐protected amino acids (ANa) and fluorinated β‐diketone/β‐diketones (BNa) in 1:1:1 molar ratio in refluxing dry benzene solution. Plausible structures of these complexes were elucidated on the basis of physicochemical and spectral studies. 119 Sn NMR spectral data revealed the presence of pentacoordinated tin centres in these dimethyltin(IV) complexes.