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Hydroformylation – amidocarbonylation of androstene and pregnene derivatives
Author(s) -
Nagy Emese,
Benedek Csilla,
Heil Bálint,
Tőrös Szilárd
Publication year - 2002
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.356
Subject(s) - chemistry , hydroformylation , rhodium , bimetallic strip , catalysis , cobalt , selectivity , ligand (biochemistry) , organic chemistry , medicinal chemistry , carbonylation , combinatorial chemistry , carbon monoxide , receptor , biochemistry
Androstene and pregnene derivatives were functionalized by amides with rhodium or binary rhodium–cobalt catalysts. Whereas the Rh–PPh 3 catalyzed reaction results in the unsaturated amido‐methylidene derivatives, the rapid hydrogenation of these compounds takes place in the presence of a basic PR 3 ligand. Using a binary rhodium–cobalt system, amidocarbonylation of the steroids occurs with high chemo‐ and regio‐selectivity. Our experiments did not support literature reports claiming the essential role of a bimetallic cluster as the active catalyst. Copyright © 2002 John Wiley & Sons, Ltd.