Hydroformylation – amidocarbonylation of androstene and pregnene derivatives | Zendy

Nagy Emese | Zendy; Benedek Csilla | Zendy; Heil Bálint | Zendy; Tőrös Szilárd | Zendy

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Hydroformylation – amidocarbonylation of androstene and pregnene derivatives

Author(s) -

Nagy Emese,

Benedek Csilla,

Heil Bálint,

Tőrös Szilárd

Publication year - 2002

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.356

Subject(s) - chemistry , hydroformylation , rhodium , bimetallic strip , catalysis , cobalt , selectivity , ligand (biochemistry) , organic chemistry , medicinal chemistry , carbonylation , combinatorial chemistry , carbon monoxide , receptor , biochemistry

Androstene and pregnene derivatives were functionalized by amides with rhodium or binary rhodium–cobalt catalysts. Whereas the Rh–PPh 3 catalyzed reaction results in the unsaturated amido‐methylidene derivatives, the rapid hydrogenation of these compounds takes place in the presence of a basic PR 3 ligand. Using a binary rhodium–cobalt system, amidocarbonylation of the steroids occurs with high chemo‐ and regio‐selectivity. Our experiments did not support literature reports claiming the essential role of a bimetallic cluster as the active catalyst. Copyright © 2002 John Wiley & Sons, Ltd.

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