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Synthesis, characterization, photoluminescence and electrochemical properties of Pt(II) and Ag(I) complexes of tetradentate aminomethylphosphine ligands and antiproliferative activities on HT‐29 human colon cancer
Author(s) -
Uruş Serhan,
İncesu Mahmut,
Köşker Seda,
Kurt Akif Hakan,
Ceyhan Gökhan
Publication year - 2017
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3550
Subject(s) - chemistry , cyclic voltammetry , thermogravimetric analysis , diamine , thiourea , aniline , electrochemistry , nuclear chemistry , metal , proton nmr , medicinal chemistry , stereochemistry , polymer chemistry , organic chemistry , electrode
Novel N 1 , N 1 , N 4 , N 4 ‐tetrakis((diphenylphosphino)methyl)benzene‐1,4‐diamine ( L1 ), N 1 , N 1 , N 5 , N 5 ‐tetrakis((diphenylphosphino)methyl)naphthalene‐1,5‐diamine ( L2 ) and 4,4′‐methylenebis( N , N ‐bis((diphenylphosphino)methyl)aniline) ( L3 ) ligands and their Pt(II) and Ag(I) complexes have been synthesized under nitrogen atmosphere using the Schlenk technique. The ligands and the complexes were characterized using 1 H NMR, 31 P NMR and Fourier transform infrared spectroscopies, thermogravimetric/differential thermal analysis, elemental analysis (C, H, N), inductively coupled plasma optical emission spectrometry (metal content), cyclic voltammetry and photoluminescence. All the complexes were investigated as anticancer agents on HT‐29 human colon cancer cell line. HT‐29 cells were treated with various concentrations (10, 25, 50, 100, 250 μM) of Pt(II) and Ag(I) tetrakisditertiaryaminomethylphosphine complexes. Cisplatin was tested at the same concentrations in order to compare the antiproliferative activities of the synthesized Pt(II) and Ag(I) complexes. Pt(II) complexes of L1 and L3 and Ag(I) complexes of L1 , L2 and L3 showed a similar inhibition effect of cancer cell proliferation when compared to cisplatin up to 50 μM; at 100 μM and higher concentrations, L1–Pt(II) and L3–Ag(I) complexes showed a much greater effect than cisplatin. Copyright © 2016 John Wiley & Sons, Ltd.