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Silver salts and DBU cooperatively catalyzed domino reaction of propargylic alcohols with trifluoromethyl ketones: direct method to trifluoromethyl‐substituted 5‐alkylidene‐1,3‐dioxolane derivatives
Author(s) -
Wang Jingjing,
Li Feng,
Xie Huanping,
Xu Mengmeng,
Zhao Xiaobo,
Liu Lantao,
Zhao WenXian
Publication year - 2017
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3545
Subject(s) - trifluoromethyl , chemistry , domino , catalysis , dioxolane , organic chemistry , combinatorial chemistry , medicinal chemistry , alkyl
A general and efficient synthesis of trifluoromethyl‐substituted 5‐alkylidene‐1,3‐dioxolanes using AgNO 3 and DBU cooperatively catalyzed domino reaction of propargylic alcohols and trifluoromethyl ketones is described. The reaction tolerates a broad range of functional groups, and the desired products are obtained in good to excellent yields (62–99%) with acceptable diastereoselectivities. Copyright © 2016 John Wiley & Sons, Ltd.