Silver salts and DBU cooperatively catalyzed domino reaction of propargylic alcohols with trifluoromethyl ketones: direct method to trifluoromethyl‐substituted 5‐alkylidene‐1,3‐dioxolane derivatives | Zendy

Wang Jingjing | Zendy; Li Feng | Zendy; Xie Huanping | Zendy; Xu Mengmeng | Zendy; Zhao Xiaobo | Zendy; Liu Lantao | Zendy; Zhao WenXian | Zendy

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Silver salts and DBU cooperatively catalyzed domino reaction of propargylic alcohols with trifluoromethyl ketones: direct method to trifluoromethyl‐substituted 5‐alkylidene‐1,3‐dioxolane derivatives

Author(s) -

Wang Jingjing,

Li Feng,

Xie Huanping,

Xu Mengmeng,

Zhao Xiaobo,

Liu Lantao,

Zhao WenXian

Publication year - 2017

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.3545

Subject(s) - trifluoromethyl , chemistry , domino , catalysis , dioxolane , organic chemistry , combinatorial chemistry , medicinal chemistry , alkyl

A general and efficient synthesis of trifluoromethyl‐substituted 5‐alkylidene‐1,3‐dioxolanes using AgNO 3 and DBU cooperatively catalyzed domino reaction of propargylic alcohols and trifluoromethyl ketones is described. The reaction tolerates a broad range of functional groups, and the desired products are obtained in good to excellent yields (62–99%) with acceptable diastereoselectivities. Copyright © 2016 John Wiley & Sons, Ltd.

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