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Di‐ n ‐butyltin aminoarylcarboxylates: structure, properties and in vitro antitumor activity
Author(s) -
Pruchnik Florian P.,
Bańbuła Małgorzata,
Ciunik Zbigniew,
Chojnacki Henryk,
Latocha Małgorzata,
Skop Barbara,
Wilczok Tadeusz
Publication year - 2002
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.347
Subject(s) - chemistry , tin , stereochemistry , crystallography , electronic structure , computational chemistry , organic chemistry
The properties and structures of the tetranuclear dibutyltin complexes [Sn 4 (µ 3 ‐O) 2 (C 4 H 9 ‐ n ) 8 {OOCC 6 H 3 (NH 2 ) 2 ‐3,4} 4 ] (1), [Sn 4 (µ 3 ‐O) 2 (C 4 H 9 ‐ n ) 8 {OOCC 6 H 3 (NH 2 ) 2 ‐3,5} 4 ] (2), [Sn 4 (µ 3 ‐O) 2 (C 4 H 9 ‐ n ) 8 {OOC‐2‐C 6 H 4 NNC 6 H 4 N(CH 3 ) 2 ‐4} 4 ] (3) are described. Complex 3 adopts a structure with a tetranuclear Sn 4 (µ 3 ‐O) 2 core. All tin atoms are five‐coordinate and form bonds with three oxygen atoms and two butyl ligands. Two carboxylates are bridging and two are terminal ligands. IR and NMR spectra indicate that the same structure is adopted by complexes 1 and 2. The molecular and electronic structures of complex 1 of C i symmetry have been studied using the semi‐empirical PM3 formalism. The calculated structure and bond distances agree with X‐ray data. All complexes are effective antitumor agents. Copyright © 2002 John Wiley & Sons, Ltd.