Premium
A practical synthesis of 2‐aminobenzothiazoles via copper(I)‐catalyzed tandem reaction of 2‐iodoanilines with isothiocyanates in ionic liquids
Author(s) -
Chen Ling,
Huang Bin,
Nie Quan,
Cai Mingzhong
Publication year - 2016
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3453
Subject(s) - chemistry , ionic liquid , yield (engineering) , catalysis , tandem , toluene , cascade reaction , copper , reaction conditions , combinatorial chemistry , organic chemistry , materials science , composite material , metallurgy
A copper(I)‐catalyzed tandem reaction of 2‐iodoanilines with isothiocyanates was achieved in hydrophobic [bmim][PF 6 ] ionic liquid under mild conditions, generating a variety of 2‐aminobenzothiazoles in good to excellent yields. The tandem reaction that was carried out in [bmim][PF 6 ] has some obvious advantages such as accelerated reaction rate and increased yield as compared with the reaction run in volatile solvents such as toluene. Furthermore, the CuI/1,10‐phenanthroline catalytic system can be reused up to eight times without loss of activity and efficiency. Copyright © 2016 John Wiley & Sons, Ltd.