A practical synthesis of 2‐aminobenzothiazoles via copper(I)‐catalyzed  tandem reaction  of 2‐iodoanilines with isothiocyanates in  ionic liquids | Zendy

Chen Ling | Zendy; Huang Bin | Zendy; Nie Quan | Zendy; Cai Mingzhong | Zendy

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A practical synthesis of 2‐aminobenzothiazoles via copper(I)‐catalyzed tandem reaction of 2‐iodoanilines with isothiocyanates in ionic liquids

Author(s) -

Chen Ling,

Huang Bin,

Nie Quan,

Cai Mingzhong

Publication year - 2016

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.3453

Subject(s) - chemistry , ionic liquid , yield (engineering) , catalysis , tandem , toluene , cascade reaction , copper , reaction conditions , combinatorial chemistry , organic chemistry , materials science , composite material , metallurgy

A copper(I)‐catalyzed tandem reaction of 2‐iodoanilines with isothiocyanates was achieved in hydrophobic [bmim][PF 6 ] ionic liquid under mild conditions, generating a variety of 2‐aminobenzothiazoles in good to excellent yields. The tandem reaction that was carried out in [bmim][PF 6 ] has some obvious advantages such as accelerated reaction rate and increased yield as compared with the reaction run in volatile solvents such as toluene. Furthermore, the CuI/1,10‐phenanthroline catalytic system can be reused up to eight times without loss of activity and efficiency. Copyright © 2016 John Wiley & Sons, Ltd.

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