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Asymmetric addition of phenylacetylene to aldehydes catalyzed by complex of O ‐sulfonyl camphor derivatives and titanium
Author(s) -
Lee DongSheng,
Gau ChangWeu,
Chen YuYang,
Lu TaJung
Publication year - 2016
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3423
Subject(s) - phenylacetylene , chemistry , camphor , sulfonyl , enantioselective synthesis , catalysis , enantiomer , organic chemistry , enantiomeric excess , titanium , medicinal chemistry , stereochemistry , alkyl
Several novel ligands that are based on the camphor skeleton or contain the O ‐sulfonyl group were synthesized and used in the asymmetric addition of phenylacetylene to aldehydes. This enantioselective reaction afforded chiral propargylic alcohols in high yields and with good to excellent levels of enantiopurity (up to 99% enantiomeric excess). Copyright © 2016 John Wiley & Sons, Ltd.