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Synthesis and biological activity of ‘3 + 1’ mixed ligand (3‐thiapentane‐1,5‐dithiolato)oxorhenium(V) complexes bearing 1,2,3,4‐tetrahydro(iso)quinoline and quinoline
Author(s) -
Zablotskaya Alla,
Segal Izolda,
Germane Skaidrite,
Shestakova Irina,
Lukevics Edmunds,
Kniess Torsten,
Spies Hartmut
Publication year - 2002
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.342
Subject(s) - chemistry , quinoline , denticity , ligand (biochemistry) , stereochemistry , metal , nuclear magnetic resonance spectroscopy , rhenium , medicinal chemistry , combinatorial chemistry , receptor , organic chemistry , biochemistry
‘3 + 1’ mixed ligand oxorhenium(V) complexes of the type ReO(SSS)S(CH 2 ) n Het N have been synthesized by the reaction of the preliminary prepared tetrahydro(iso)quinolyl containing monodentate ligands with chloro(3‐thiapentane‐1,5‐dithiolato)oxorhenium(V). The newly synthesized ligands and complexes were characterized by elemental analysis, IR, 1 H, and 13 C NMR spectroscopy. Metal complexes were screened for psychotropic and antitumour activities and receptor‐binding properties and were found to be active in this respect. Copyright © 2002 John Wiley & Sons, Ltd.