One‐pot, four‐component synthesis of 1,3,4‐oxadiazole derivatives containing a ferrocene unit and their  antimicrobial activity | Zendy

Kazemizadeh Ali Reza | Zendy; Shajari Nahid | Zendy; Shapouri Reza | Zendy; Adibpour Neda | Zendy; TeimuriMofrad Reza | Zendy; Dinmohammadi Parisa | Zendy

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One‐pot, four‐component synthesis of 1,3,4‐oxadiazole derivatives containing a ferrocene unit and their antimicrobial activity

Author(s) -

Kazemizadeh Ali Reza,

Shajari Nahid,

Shapouri Reza,

Adibpour Neda,

TeimuriMofrad Reza,

Dinmohammadi Parisa

Publication year - 2016

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.3410

Subject(s) - chemistry , ferrocene , antimicrobial , oxadiazole , yield (engineering) , combinatorial chemistry , component (thermodynamics) , staphylococcus aureus , in vivo , pseudomonas aeruginosa , in vitro , organic chemistry , bacteria , biochemistry , electrochemistry , microbiology and biotechnology , materials science , physics , genetics , electrode , biology , metallurgy , thermodynamics

A four‐component reaction between aromatic carboxylic acids , ( N ‐isocyanimino)triphenylphosphorane, ferrocenecarbaldehyde and dibenzylamine is reported. This approach is an efficient, simple and high‐yield procedure for the synthesis of 1,3,4‐oxadiazole derivatives containing a ferrocene unit. The antimicrobial activities of the products were investigated against Staphylococcus aureus and Pseudomonas aeruginosa in in vitro and in vivo assays. Copyright © 2015 John Wiley & Sons, Ltd.

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