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One‐pot, four‐component synthesis of 1,3,4‐oxadiazole derivatives containing a ferrocene unit and their antimicrobial activity
Author(s) -
Kazemizadeh Ali Reza,
Shajari Nahid,
Shapouri Reza,
Adibpour Neda,
TeimuriMofrad Reza,
Dinmohammadi Parisa
Publication year - 2016
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3410
Subject(s) - chemistry , ferrocene , antimicrobial , oxadiazole , yield (engineering) , combinatorial chemistry , component (thermodynamics) , staphylococcus aureus , in vivo , pseudomonas aeruginosa , in vitro , organic chemistry , bacteria , biochemistry , electrochemistry , microbiology and biotechnology , materials science , physics , genetics , electrode , biology , metallurgy , thermodynamics
A four‐component reaction between aromatic carboxylic acids , ( N ‐isocyanimino)triphenylphosphorane, ferrocenecarbaldehyde and dibenzylamine is reported. This approach is an efficient, simple and high‐yield procedure for the synthesis of 1,3,4‐oxadiazole derivatives containing a ferrocene unit. The antimicrobial activities of the products were investigated against Staphylococcus aureus and Pseudomonas aeruginosa in in vitro and in vivo assays. Copyright © 2015 John Wiley & Sons, Ltd.