Palladium(II) and bidentate phosphine‐catalyzed selective synthesis of  N ‐aryl‐2‐pyrrolidinones via cyclocarbonylative coupling of 2‐aminophenol and 2‐aminothiophenol | Zendy

Longo Luigia | Zendy; Mele Giuseppe | Zendy; Ciccarella Giuseppe | Zendy; Sgobba Vito | Zendy; Ali Bassam El | Zendy; Vasapollo Giuseppe | Zendy

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Palladium(II) and bidentate phosphine‐catalyzed selective synthesis of N ‐aryl‐2‐pyrrolidinones via cyclocarbonylative coupling of 2‐aminophenol and 2‐aminothiophenol

Author(s) -

Longo Luigia,

Mele Giuseppe,

Ciccarella Giuseppe,

Sgobba Vito,

Ali Bassam El,

Vasapollo Giuseppe

Publication year - 2002

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.338

Subject(s) - chemistry , pyrrolidinones , palladium , phosphine , catalysis , regioselectivity , aryl , amination , butane , medicinal chemistry , denticity , polymer chemistry , organic chemistry , alkyl , crystal structure

The inter‐ and intra‐molecular regioselective cyclocarbonylative coupling of 2‐aminophenol ( 1a ) and 2‐aminothiophenol ( 1b ) with various allylhalides was achieved in the presence of a catalytic amount of palladium acetate and 1,4‐bis(diphenylphosphino)butane to afford N ‐aryl‐2‐pyrrolidinones ( 3 , 4 ) in 47–65% yields. Other aminophenol derivatives have also been used and gave good yields of the corresponding N ‐aryl‐2‐pyrrolidinones. Copyright © 2002 John Wiley & Sons, Ltd.

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