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3‐(Diphenylphosphino)propanoic acid: an efficient ligand for the Pd/Cu‐catalyzed homo‐coupling of terminal alkynes in the presence of oxygen at room temperature
Author(s) -
Liu Yashuai,
Gu Ningning,
Liu Ping,
Xie Jianwei,
Ma Xiaowei,
Liu Yan,
Dai Bin
Publication year - 2015
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3359
Subject(s) - propanoic acid , chemistry , ligand (biochemistry) , catalysis , oxygen , terminal (telecommunication) , medicinal chemistry , coupling (piping) , oxygen atom , stereochemistry , combinatorial chemistry , organic chemistry , molecule , receptor , mechanical engineering , telecommunications , biochemistry , computer science , engineering
A simple, yet efficient system for PdCl 2 /CuI to catalyze the homo‐coupling reactions of various terminal alkynes has been developed using 3‐(diphenylphosphino)propanoic acid as ligand in the presence of oxygen. The alkynes, including aromatic, heteroaromatic and aliphatic alkynes, were transformed at room temperature into the corresponding 1,3‐diynes in moderate to excellent yields. The turnover number was up to 1.04 × 10 3 . Copyright © 2015 John Wiley & Sons, Ltd.