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Synthesis, crystal structure and cytotoxic activity of tricyclohexyltin complexes of benzenedioxyacetic acids
Author(s) -
Tian Laijin,
Yu Haixia,
Zheng Xiaoliang,
Liu Xijie
Publication year - 2015
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3357
Subject(s) - chemistry , tin , carboxylate , hela , hydrogen bond , supramolecular chemistry , infrared spectroscopy , stereochemistry , crystal structure , crystallography , ligand (biochemistry) , proton nmr , molecule , in vitro , organic chemistry , receptor , biochemistry
Two new bis(tricyclohexyltin)benzenedioxyacetates, 1, x ‐C 6 H 4 [OCH 2 CO 2 Sn( c ‐C 6 H 11 ) 3 ] 2 ( 1 : x = 3; 2 : x = 4), have been synthesized and characterized by means of elemental analysis, infrared and NMR ( 1 H, 13 C and 119 Sn) spectra and single‐crystal X‐ray diffraction. Compound 1 ⋅H 2 O⋅CH 3 OH is a binuclear tin complex containing a four‐coordinated tin and a five‐coordinated tin and linked by an R 3 3 (16) hydrogen bond into a one‐dimensional supramolecular chain. Compound 2 is a two‐dimensional coordination polymer which is formed as a result of anisobidentate bridging coordination action of the two carboxylate units of the ligand. Interestingly the two‐dimensional coordination polymer contains 34‐membered macrocycles each of which is comprised of four tricyclohexyltin units. Both compounds have potent in vitro cytotoxic activity against three human tumor cell lines: HeLa, MCF‐7 and CoLo 205. Copyright © 2015 John Wiley & Sons, Ltd.