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Palladium‐catalysed reductive carbonylation of aryl halides with iron pentacarbonyl for synthesis of aromatic aldehydes and deuterated aldehydes
Author(s) -
Iranpoor Nasser,
Firouzabadi Habib,
EtemadiDavan Elham,
Rostami Abed,
Rajabi Moghadam Khashayar
Publication year - 2015
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3356
Subject(s) - chemistry , aryl , carbonylation , ligand (biochemistry) , palladium , reductive elimination , iron pentacarbonyl , halide , organic chemistry , aldehyde , aryl halide , catalysis , dimethylformamide , medicinal chemistry , carbon monoxide , alkyl , biochemistry , receptor , solvent
The first use of iron pentacarbonyl is described for the novel and efficient conversion of aryl iodides, bromides and chlorides into their corresponding aryl aldehydes and/or aryl deuterated aldehydes. The reaction is catalysed with Pd(0) in aqueous N,N ‐dimethylformamide at atmospheric pressure. In this protocol, neither gaseous hydrogen nor any reducing agent is required for the formation of the carbonylated product. The reaction can be performed without a P(III) ligand for aryl iodides; however, employing a P(III) ligand is necessary to perform the reaction with aryl bromides and chlorides. Copyright © 2015 John Wiley & Sons, Ltd.