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The thermoregulated ligand–palladium‐catalyzed carbonylative Sonogashira coupling of aryl iodides with terminal alkynes in water
Author(s) -
Hao Yuanping,
Jiang Jingyang,
Wang Yanhua,
Jin Zilin
Publication year - 2015
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3337
Subject(s) - sonogashira coupling , chemistry , catalysis , aryl , palladium , carbon monoxide , ligand (biochemistry) , carbonylation , combinatorial chemistry , organic chemistry , medicinal chemistry , biochemistry , alkyl , receptor
The carbonylative Sonogashira coupling of aryl iodides with terminal alkynes was studied by using thermoregulated ligand–palladium as an efficient and reusable catalyst at 80 °C in water. The corresponding alkynone products were obtained in good to excellent yields under 1 atm of carbon monoxide . The isolation of the products was readily achieved by extraction with ethyl acetate, and the catalyst recovered in water can be reused and recycled up to four times without significant loss in catalytic activity . Copyright © 2015 John Wiley & Sons, Ltd.