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Desulfitative palladium‐catalyzed direct C‐3 arylation of indolizines with arylsulfonyl chlorides
Author(s) -
Zhang Wei,
Liu Fang,
Zhao Baoli
Publication year - 2015
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3326
Subject(s) - chemistry , indolizine , palladium , triphenylphosphine , reagent , dimethoxyethane , catalysis , ligand (biochemistry) , combinatorial chemistry , solvent , organic chemistry , medicinal chemistry , biochemistry , receptor , electrode , electrolyte
An efficient Pd‐catalyzed desulfitative approach to C‐3 arylation of indolizine derivatives has been developed, and the protocol uses readily available arylsulfonyl chlorides as the arylation reagent under nitrogen. This transformation was performed in a mixed solvent of 1‐methyl‐2‐pyrrolidone and dimethoxyethane using simple triphenylphosphine as a ligand, which provides a new method for the C‐3 arylation of indolizines. Copyright © 2015 John Wiley & Sons, Ltd.