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Zn( L ‐proline) 2 as a powerful and reusable organometallic catalyst for the very fast synthesis of 2‐amino‐4 H ‐benzo[ g ]chromene derivatives under solvent‐free conditions
Author(s) -
Maleki Behrooz,
Babaee Saeed,
Tayebee Reza
Publication year - 2015
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3306
Subject(s) - chemistry , malononitrile , catalysis , proline , amino acid , organometallic chemistry , combinatorial chemistry , organic chemistry , stereochemistry , medicinal chemistry , biochemistry
An efficient route for the synthesis of 2‐amino‐4 H ‐benzo[ g ]chromenes via a three‐component coupling reaction of aldehydes, malononitrile and 2‐hydroxy‐1,4‐naphthaquinone in the presence of Zn( L ‐proline) 2 is reported. High yields, short reaction times, non‐toxicity and recyclability of the catalyst, and easy work‐up are the main merits of this protocol. Copyright © 2015 John Wiley & Sons, Ltd.