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CuBr/proline‐catalyzed cross‐coupling of unactivated benzene with aryl halides
Author(s) -
Liu Wei,
Hou Fanyi
Publication year - 2015
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3300
Subject(s) - chemistry , homolysis , aryl , benzene , catalysis , halide , ligand (biochemistry) , copper , coupling reaction , electrophilic aromatic substitution , medicinal chemistry , combinatorial chemistry , base (topology) , proline , organic chemistry , polymer chemistry , radical , alkyl , mathematical analysis , biochemistry , receptor , mathematics , amino acid
Direct CH arylation of unactivated benzene with aryl halides was achieved using a readily available copper catalyst. The reaction was carried out at 80 °C, using CuBr as catalyst, proline as ligand and t ‐BuOK as base. This radical cross‐coupling reaction between unactivated benzene and aryl iodides proceeds via homolytic aromatic substitution and offers an efficient method for the synthesis of various biaryls in good to excellent yields. Copyright © 2015 John Wiley & Sons, Ltd.