Cytotoxicological aspects of the organic arsenic compound arsenobetaine in marine animals | Zendy

Kojima Chikara | Zendy; Sakurai Teruaki | Zendy; Ochiai Masayuki | Zendy; Kumata Hidetoshi | Zendy; Qu Wei | Zendy; Waalkes Michael P. | Zendy; Fujiwara Kitao | Zendy

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Cytotoxicological aspects of the organic arsenic compound arsenobetaine in marine animals

Author(s) -

Kojima Chikara,

Sakurai Teruaki,

Ochiai Masayuki,

Kumata Hidetoshi,

Qu Wei,

Waalkes Michael P.,

Fujiwara Kitao

Publication year - 2002

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.328

Subject(s) - chemistry , cytotoxicity , arsenobetaine , glutathione , biochemistry , secretion , nitric oxide , in vitro , macrophage , arsenite , microbiology and biotechnology , arsenic , enzyme , organic chemistry , biology

In this study, we investigated the in vitro cytotoxicity of arsenobetaine [AsBe; trimethyl (carboxymethyl) arsonium zwitterion], which is a major organic arsenic compound in marine animals, to various mammalian cells, such as mouse macrophage RAW264.7 cells, rat liver TRL1215 cells and human skin TIG‐112 cells, using a synthetic pure material. As a result, we demonstrated that the cytotoxicity of AsBe is very weak even at concentrations over 20 mmol dm −3 in all these cells. Also, AsBe did not affect various functions of the murine macrophage RAW264.7 cells, viz interleukin‐1α production, cellular lysosomal enzyme (acid phosphatase) activity and nitric oxide (NO 2 − ) secretion. AsBe showed a weak effect on the reduced glutathione (GSH) levels in these cells, and it slightly reduced the cellular GSH levels for a while. These data suggest that AsBe shows no cytotoxicity but has some effects on mammalian cells. Copyright © 2002 John Wiley & Sons, Ltd.

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