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Novel organosilicon dendrons as effective linkers for biomolecules binding on a glass surface
Author(s) -
Hreczycho Grzegorz,
FrydrychTomczak Emilia,
Sterzynska Karolina,
Budna Joanna,
Malinska Agnieszka,
Maciejewski Hieronim,
Zabel Maciej
Publication year - 2015
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3272
Subject(s) - hydrosilylation , chemistry , organosilicon , substituent , amine gas treating , combinatorial chemistry , biomolecule , surface modification , platinum , epoxy , polymer chemistry , stereochemistry , catalysis , organic chemistry , biochemistry
A new, flexible and selective protocol for the synthesis of new organofunctional silicon dendrons of the general formula EtOSi(CH 2 CH 2 SiMe 2 CH 2 CH 2 SiMe 2 R) 3 (where R is an amine or epoxy substituent) has been developed. The title compounds have been efficiently obtained via Karstedt platinum‐catalysed hydrosilylation and linked to a glass surface. Modified solid supports are successfully applied in immobilization of proteins, especially monoclonal antibodies against a wide range of antigens. Copyright © 2015 John Wiley & Sons, Ltd.