Novel organosilicon dendrons as effective linkers for biomolecules binding on a glass surface | Zendy

Hreczycho Grzegorz | Zendy; FrydrychTomczak Emilia | Zendy; Sterzynska Karolina | Zendy; Budna Joanna | Zendy; Malinska Agnieszka | Zendy; Maciejewski Hieronim | Zendy; Zabel Maciej | Zendy

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Novel organosilicon dendrons as effective linkers for biomolecules binding on a glass surface

Author(s) -

Hreczycho Grzegorz,

FrydrychTomczak Emilia,

Sterzynska Karolina,

Budna Joanna,

Malinska Agnieszka,

Maciejewski Hieronim,

Zabel Maciej

Publication year - 2015

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.3272

Subject(s) - hydrosilylation , chemistry , organosilicon , substituent , amine gas treating , combinatorial chemistry , biomolecule , surface modification , platinum , epoxy , polymer chemistry , stereochemistry , catalysis , organic chemistry , biochemistry

A new, flexible and selective protocol for the synthesis of new organofunctional silicon dendrons of the general formula EtOSi(CH 2 CH 2 SiMe 2 CH 2 CH 2 SiMe 2 R) 3 (where R is an amine or epoxy substituent) has been developed. The title compounds have been efficiently obtained via Karstedt platinum‐catalysed hydrosilylation and linked to a glass surface. Modified solid supports are successfully applied in immobilization of proteins, especially monoclonal antibodies against a wide range of antigens. Copyright © 2015 John Wiley & Sons, Ltd.

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