Direct  arylation  of imidazo[2,1‐ b ]thiazoles and thiazoles with aryl iodides via CuCl 2 /PPh 3 ‐catalyzed  C–H bond functionalization | Zendy

Ma Yuchang | Zendy; Na Min | Zendy; Gu Yanfang | Zendy; Huang Guoli | Zendy; Li Xia | Zendy; Chen Yegao | Zendy

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Direct arylation of imidazo[2,1‐ b ]thiazoles and thiazoles with aryl iodides via CuCl 2 /PPh 3 ‐catalyzed C–H bond functionalization

Author(s) -

Ma Yuchang,

Na Min,

Gu Yanfang,

Huang Guoli,

Li Xia,

Chen Yegao

Publication year - 2015

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.3263

Subject(s) - chemistry , aryl , disproportionation , catalysis , surface modification , combinatorial chemistry , ligand (biochemistry) , medicinal chemistry , copper , stereochemistry , organic chemistry , alkyl , receptor , biochemistry

With PPh 3 acting as a ligand, a convenient method for CuCl 2 ‐catalyzed arylation of imidazo[1,2‐ b ]thiazoles and thiazoles with aryl iodides under mild reaction conditions is described. Preliminary mechanistic studies of this arylation involving a formal Cu(I) to Cu(0) and Cu(II) route by convergent disproportionation of the copper mediator are also reported. Copyright © 2015 John Wiley & Sons, Ltd.

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