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Direct arylation of imidazo[2,1‐ b ]thiazoles and thiazoles with aryl iodides via CuCl 2 /PPh 3 ‐catalyzed C–H bond functionalization
Author(s) -
Ma Yuchang,
Na Min,
Gu Yanfang,
Huang Guoli,
Li Xia,
Chen Yegao
Publication year - 2015
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3263
Subject(s) - chemistry , aryl , disproportionation , catalysis , surface modification , combinatorial chemistry , ligand (biochemistry) , medicinal chemistry , copper , stereochemistry , organic chemistry , alkyl , receptor , biochemistry
With PPh 3 acting as a ligand, a convenient method for CuCl 2 ‐catalyzed arylation of imidazo[1,2‐ b ]thiazoles and thiazoles with aryl iodides under mild reaction conditions is described. Preliminary mechanistic studies of this arylation involving a formal Cu(I) to Cu(0) and Cu(II) route by convergent disproportionation of the copper mediator are also reported. Copyright © 2015 John Wiley & Sons, Ltd.