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Design, synthesis and in vitro cytotoxicity of novel dinuclear platinum(II) complexes with a tetradentate carrier ligand
Author(s) -
Gao ChuanZhu,
Wang TianShuai,
Zhang Yan,
Chen Ji,
Qian YunXu,
Yang Bo,
Zhang YingJie
Publication year - 2015
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3257
Subject(s) - chemistry , cytotoxicity , carboplatin , ligand (biochemistry) , platinum , in vitro , mtt assay , stereochemistry , cell culture , a549 cell , combinatorial chemistry , cisplatin , receptor , biochemistry , chemotherapy , medicine , surgery , biology , genetics , catalysis
Four novel dinuclear platinum complexes with a tetradentate ligand, (1R,1′R,2R,2′R)‐N 1 ,N 1′ ‐(1,2‐phenylenebis(methylene))dicyclohexane‐1,2‐diamine, as the carrier group, have been designed, synthesized and characterized, and their in vitro cytotoxicity against HepG‐2, A549, HCT‐116 and MCF‐7 cell lines evaluated using MTT assay. Results indicate that the targeted dinuclear platinum complexes H1 , H2 , H3 , H4 exhibit significant growth inhibitory properties against HepG‐2, A549 and HCT‐116 cell lines, but none of them show activity against MCF‐7 cell line. Compound H4 shows better antitumor activity than carboplatin against HepG‐2, A549 and HCT‐116 cell lines. Copyright © 2015 John Wiley & Sons, Ltd.