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One‐pot synthesis of polyfluoroterphenyls via palladium‐catalyzed Suzuki–Miyaura coupling of chlorobromobenzene and CH bond functionalization of perfluoroarenes
Author(s) -
Ma Xiaowei,
Gu Ningning,
Liu Yan,
Liu Ping,
Xie Jianwei,
Dai Bin,
Liu Zhiyong
Publication year - 2015
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3248
Subject(s) - chemistry , palladium , catalysis , tandem , surface modification , combinatorial chemistry , coupling reaction , crystal structure , cascade reaction , polymer chemistry , organic chemistry , materials science , composite material
An efficient tandem route for the synthesis of polyfluoroterphenyl derivatives has been developed. The target compounds were obtained in moderate to good yields by a Pd(OAc) 2 ‐catalyzed three‐component coupling reaction involving palladium‐catalyzed direct CH activation of perfluoroarenes. This in turn will set the stage for a wide application of this useful reaction for the synthesis of fluorinated liquid crystal compounds containing the privileged polyfluoroterphenyl structure. Copyright © 2014 John Wiley & Sons, Ltd.