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l ‐Proline: an efficient N,O‐bidentate ligand for copper‐catalyzed intramolecular cyclization reaction of 2‐iodoanilines with nitriles for the synthesis of benzimidazoles
Author(s) -
Yu Jiatao,
Xia Yonggen,
Lu Ming
Publication year - 2014
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3195
Subject(s) - chemistry , benzimidazole , intramolecular force , catalysis , ligand (biochemistry) , denticity , proline , copper , combinatorial chemistry , reaction conditions , medicinal chemistry , stereochemistry , organic chemistry , receptor , metal , amino acid , biochemistry
A novel and highly efficient copper‐catalyzed intramolecular cyclization reaction of 2‐iodoanilines with nitriles for the synthesis of benzimidazoles with l ‐proline as the ligand has been developed. A variety of substituted benzimidazole derivatives can be synthesized with high yields using this approach. Copyright © 2014 John Wiley & Sons, Ltd.