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Palladium‐catalyzed synthesis of 6‐allylcoumarins using organotin reagents as multicoupling organometallic nucleophiles
Author(s) -
Yan Han,
Yin Wenzheng,
Liu Pin,
Liu Jia,
Hu Meichen,
Gu Cheng,
Yao Yang,
Zhang Weihua
Publication year - 2014
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3188
Subject(s) - chemistry , palladium , stille reaction , nucleophile , catalysis , reagent , organometallic chemistry , dimethylformamide , group 2 organometallic chemistry , organic chemistry , coupling reaction , combinatorial chemistry , molecule , solvent
Derivatives of 6‐iodocoumarin undergoing a direct Stille cross‐coupling reaction with organotin compounds in the presence of a catalytic amount of Pd(PPh 3 ) 4 in dimethylformamide at 80°C is described in this study. It is the first report of the palladium‐catalyzed coupling of iodocoumarins with allyltributyltin under mild conditions to form alkylcoumarin compounds in good yields. © 2014 The Authors. Applied Organometallic Chemistry published by John Wiley & Sons, Ltd.