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Synthesis, characterization, molecular modelling and biological activity of 2‐(pyridin‐1‐ium‐1‐yl) acetate and its Cu 2+ , Pt 4+ , Pd 2+ , Au 3+ and Nd 3+ complexes
Author(s) -
Mlahi Mosaad R.,
Negm Amr,
Azhari Shaker J.,
Mostafa Mohsen M.
Publication year - 2014
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3187
Subject(s) - chemistry , denticity , ligand (biochemistry) , homo/lumo , stereochemistry , octahedral molecular geometry , bond length , proton nmr , octahedron , carbon 13 nmr , medicinal chemistry , crystallography , molecule , crystal structure , organic chemistry , biochemistry , receptor
A new series of Cu 2+ , Pt 4+ , Pd 2+ , Au 3+ and Nd 3+ complexes derived from 2‐(pyridin‐1‐ium‐1‐yl) acetate have been synthesized and characterized using elemental analyses, spectral (infrared (IR), UV–visible, mass, 13 C NMR and 1 H NMR), magnetic and thermal measurements. IR results suggest that the ligand acts in a neutral monodentate fashion in all complexes. Octahedral geometry is proposed for Cu 2+ and Pt 4+ complexes and square‐planar for Pd 2+ and Au 3+ complexes. The bond lengths, bond angles, and HOMO and LUMO were calculated. Superoxide dismutase‐like radical scavenger activity and cytotoxic activity of the isolated complexes on HepG2 liver cancer cells have been screened. Ligand and complexes (Pt 4+ and Nd 3+ ) exhibit potent antioxidant activity upon coordination while Cu 2+ and Au 3+ complexes do not show superoxide dismutase‐like radical scavenger activity. The cytotoxic activity assay against HepG2 cell line proves that the ligand and its Pt 4+ complex have a high cytotoxic activity, while the other complexes showed no cytotoxic activity. Copyright © 2014 John Wiley & Sons, Ltd.