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(BeDABCO) 2 Pd 2 Cl 6 as an efficient homogeneous catalyst for copper‐free Sonogashira cross‐coupling reaction
Author(s) -
Hajipour Abdol R.,
Rafiee Fatemeh
Publication year - 2014
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3167
Subject(s) - chemistry , sonogashira coupling , phenylacetylene , catalysis , dabco , halide , chloride , copper , octane , palladium , copper(ii) chloride , aryl , copper chloride , homogeneous catalysis , bromide , ammonium chloride , amination , inorganic chemistry , organic chemistry , alkyl
An efficient catalytic system using 1‐benzyl‐4‐aza‐1‐azoniabicyclo[2.2.2]octane chloride and palladium chloride ((BeDABCO) 2 Pd 2 Cl 6 ) was developed for the Sonogashira reaction . In the presence of a catalytic amount of this efficient, stable homogeneous catalytic system that is non‐sensitive to air and moisture, various aryl halides were efficiently coupled with phenylacetylene in good yields in H 2 O at 50°C under copper‐free conditions. Benzyl dabco as an efficient ligand and also a quaternary ammonium salt had an efficient stabilizing effect on the Pd(0) species. Copyright © 2014 John Wiley & Sons, Ltd.