Palladium‐catalyzed  carbonylative cyclization  of β‐bromo‐α,β‐unsaturated  carboxylic acids  with 2,2‐dimethylhydrazine leading to 1‐(dimethylamino)‐1 H ‐pyrrole‐2,5‐diones | Zendy

Bae Yeon Kyu | Zendy; Cho Chan Sik | Zendy

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Palladium‐catalyzed carbonylative cyclization of β‐bromo‐α,β‐unsaturated carboxylic acids with 2,2‐dimethylhydrazine leading to 1‐(dimethylamino)‐1 H ‐pyrrole‐2,5‐diones

Author(s) -

Bae Yeon Kyu,

Cho Chan Sik

Publication year - 2014

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.3111

Subject(s) - chemistry , palladium , catalysis , dimethylhydrazine , pyrrole , carbon monoxide , medicinal chemistry , carbonylation , organic chemistry , base (topology) , polymer chemistry , mathematical analysis , mathematics , medicine , colorectal cancer , cancer

β‐Bromo‐α,β‐unsaturated carboxylic acids are carbonylatively cyclized with 2,2‐dimethylhydrazine under carbon monoxide pressure in THF in the presence of a catalytic amount of a palladium catalyst along with a base to give 1‐(dimethylamino)‐1 H ‐pyrrole‐2,5‐diones. Copyright © 2014 John Wiley & Sons, Ltd.

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