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Palladium‐catalyzed carbonylative cyclization of β‐bromo‐α,β‐unsaturated carboxylic acids with 2,2‐dimethylhydrazine leading to 1‐(dimethylamino)‐1 H ‐pyrrole‐2,5‐diones
Author(s) -
Bae Yeon Kyu,
Cho Chan Sik
Publication year - 2014
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3111
Subject(s) - chemistry , palladium , catalysis , dimethylhydrazine , pyrrole , carbon monoxide , medicinal chemistry , carbonylation , organic chemistry , base (topology) , polymer chemistry , mathematical analysis , mathematics , medicine , colorectal cancer , cancer
β‐Bromo‐α,β‐unsaturated carboxylic acids are carbonylatively cyclized with 2,2‐dimethylhydrazine under carbon monoxide pressure in THF in the presence of a catalytic amount of a palladium catalyst along with a base to give 1‐(dimethylamino)‐1 H ‐pyrrole‐2,5‐diones. Copyright © 2014 John Wiley & Sons, Ltd.