Palladium‐catalyzed direct arylation of polyfluoroarene and facile synthesis of liquid crystal compounds | Zendy

Ma Xiaowei | Zendy; Liu Yan | Zendy; Liu Ping | Zendy; Xie Jianwei | Zendy; Dai Bin | Zendy; Liu Zhiyong | Zendy

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Palladium‐catalyzed direct arylation of polyfluoroarene and facile synthesis of liquid crystal compounds

Author(s) -

Ma Xiaowei,

Liu Yan,

Liu Ping,

Xie Jianwei,

Dai Bin,

Liu Zhiyong

Publication year - 2014

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.3106

Subject(s) - chemistry , catalysis , yield (engineering) , palladium , halide , aryl , toluene , alkyl , solvent , organic chemistry , base (topology) , combinatorial chemistry , medicinal chemistry , mathematical analysis , materials science , mathematics , metallurgy

A convenient approach has been developed to prepare polyfluorobiphenyl by Pd(OAc) 2 /PCy 3 ‐catalyzed direct arylation of polyfluoroarenes with aromatic halides in the presence of Cs 2 CO 3 as base and toluene as solvent. In most cases, the desired arylated products of aromatic bromides were obtained in good to excellent yield at 80°C, and aryl chlorides also gave modest to good yields of arylated products at 110°C. According to this efficient C―C bondforming method, polyfluorobiphenyl liquid crystal compounds were prepared by Pd‐catalyzed direct arylation reactions of polyfluoroarenes with long alkyl chain substituted aryl bromides in 62–96% yield. Copyright © 2014 John Wiley & Sons, Ltd.

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