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Ligand‐free CuTC‐catalyzed N ‐arylation of amides, anilines and 4‐aminoantipyrine: synthesis of N ‐arylacrylamides, 4‐amido‐ N ‐phenylbenzamides and 4‐amino( N ‐phenyl)antipyrenes
Author(s) -
Quan ZhengJun,
Xia HaiDong,
Zhang Zhang,
Da YuXia,
Wang XiCun
Publication year - 2014
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3080
Subject(s) - chemistry , catalysis , ligand (biochemistry) , aryl , medicinal chemistry , copper , organic chemistry , combinatorial chemistry , receptor , biochemistry , alkyl
N ‐Arylation of amides and anilines with aryl iodides was efficiently catalyzed by copper thiophenecarboxylate under ligand‐free conditions with good to excellent yields. A variety of substituted aryl iodides, amides, anilines and 4‐aminoantipyrine were found to be applicable to the simple catalytic system. Furthermore, some practical, unique secondary amides, such as N ‐arylacrylamides and 4‐amido‐ N ‐phenylbenzamides, and 4‐amino( N ‐phenyl)antipyrenes, which are difficult to obtain by the classical methods, were prepared. Copyright © 2013 John Wiley & Sons, Ltd.