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Carbene adduct of cyclopalladated ferrocenylimine‐assisted synthesis of aminopyridine derivatives by the amination of chloropyridines with primary and secondary amines
Author(s) -
Mu Bing,
Li Jingya,
Wu Yangjie
Publication year - 2013
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3026
Subject(s) - chemistry , amination , adduct , carbene , steric effects , alkyl , primary (astronomy) , medicinal chemistry , combinatorial chemistry , organic chemistry , polymer chemistry , catalysis , physics , astronomy
An efficient, simple way to synthesize aminopyridine derivatives is presented, based on Buchwald–Hartwig aminations . Using 1 mol% N ‐heterocyclic carbene adduct of cyclopalladated ferrocenylimine in the presence of 1.5 equiv. t BuOK as base in dioxane at 110°C offered moderate to excellent yields in the reaction of chloropyridines with primary and secondary amines, including sterically hindered amines and alkyl amines.