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Structure and in vitro antifungal activity of [2,6‐bis(dimethylaminomethyl)phenyl]diphenyltin(IV) compounds
Author(s) -
Růžic̆ka Aleš,
Dostál Libor,
Jambor Roman,
Buchta Vladimír,
Brus Jir̆í,
Císar̆ová Ivana,
Holc̆apek Michal,
Holec̆ek Jaroslav
Publication year - 2002
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.302
Subject(s) - chemistry , nuclear magnetic resonance spectroscopy , electrospray ionization , ionic bonding , antifungal , stereochemistry , mass spectrometry , medicinal chemistry , organic chemistry , ion , chromatography , medicine , dermatology
A set of seven [2,6‐bis(dimethylaminomethyl)phenyl]diphenyltin(IV) ({[(CH 3 ) 2 NCH 2 ] 2 (C 6 H 3 )}(C 6 H 5 ) 2 Sn + X − ) ionic organotin(IV) compounds (X = Br, NO 3 , CN, SCN, SeCN, BF 4 and PF 6 ) has been prepared and characterized by electrospray ionization mass spectrometry, 1 H NMR spectroscopy in CDCl 3 , 119 Sn NMR in CDCl 3 and DMSO‐ d 6 solution, as well as by 13 C and 119 Sn CP/MAS NMR spectroscopy and X‐ray diffraction techniques in the solid state. The in vitro antifungal activity of these water‐soluble ionic organotin(IV) compounds was compared with starting compounds and the antifungal drugs currently in clinical use. Copyright © 2002 John Wiley & Sons, Ltd.